MOONLIGHT’S QUEST
Sire: Hylowe’s Moonlight Storm
Dam: Richelle’s Luv-N-Shadow
Owners: Gloria Erskine and Richelle Spencer
Breeder: Gloria Erskine
March 3, 1996 – April 5, 2007
11 years, 1 month
Checklist of common diseases:
Yes | No | |
Cancer Mammary Hemangiosarcoma Other |
X X X |
|
Digestive system EPI IBD Perianal fistulas |
X X X |
|
Endocrine System Addison's disease Hypothyroidism |
X X |
|
Heart and Vascular system diseases | X | |
Immune system diseases | X | |
Skin diseases | X | |
Liver/Pancreatic | X | |
Skeletal diseases Elbow dysplasia Hip dysplasia Intervertebral disc disease Lumbosacral stenosis Panosteitis Spondylosis |
X/+++ X/+ X/+++ X/++ |
X X |
Neurological conditions GSD degenerative myelopathy |
X |
|
Ocular diseases Cataracts Pannus Corneal dystrophy |
X X X |
|
Non-genetic symptoms/side effects of other conditions Arthritis (DJD) Bladder atony Megacolon |
X(stifles) |
X X |
Other
Seizures/Epilepsy X
Interpretation of necropsy results:
Quest was euthanized due to loss of control of his hindquarters. There
was visual evidence of both arthritis bridging the first four lumbar
vertebrae (spondylosis) and intervertebral disc disease. The severity of the disc disease increases when moving from head to tail of the dog. There
was moderate spinal cord compression in the region of L2-L3, and marked
compression at L3-L4, which could have resulted in the clinical
symptoms that Quest was displaying. There is also bridging spondylosis of the second through 13th thoracic vertebrae. The
microscopic examination of the spinal cord revealed only mild changes
in no specific regions, and the compression visible grossly was not
marked by microscopic evidence of chronic compression. Usually
there is a specific type of degenerative change associated with chronic
compressive spinal cord lesions (Wallerian degeneration) which was not
noted on microscopic exam. There was build
up of lipofuscin (pale yellow pigment granules) within many nerve
cells, and mild degeneration of the myelin coating of several areas of
the spinal cord, but this is consistent with age-related change and not
specific to the symptoms that Quest displayed.
There is also a history of dysplasia of the hips and elbows, and arthritis of the stifle joints. This
was confirmed on necropsy examination, with only mild changes to the
cartilage of the femoral heads of the hips joints, but more severe
changes in elbows and stifles. The elbows
displayed remodeling of the cartilage protecting the joint, and
formation of osteophytes (bone spurs,) several of which were floating
free in the left elbow joint. This is often called a “joint mouse” and can cause significant pain and diminished function.
There was mild diffuse congestion of the liver and lungs that was most likely secondary to the medications used for euthanasia. There was moderate to severe arteriosclerosis of some of the vessels of the heart. It
is possible that over time there would be some compromise of oxygen
supply to the muscles of the heart (cardiac musculature,) but there was
no significant alteration to the heart yet on exam. There
were age-related changes in the kidneys, which involve thickening of
some areas of the membranes similar to scar tissue, and atrophy of some
of the functional areas of the kidney. The
skin of the lower lips showed moderate to severe infiltrate of plasma
cells in the superficial and deep layers, termed plasmacytic dermatitis
(“lip fold dermatitis.”) There was no evidence of cancer, nor any disease in the digestive system, endocrine system, immune system, or eyes.